Table 1 Positional and functional candidate genes associated with innate humoral immune response
From: In silico analysis of candidate genes associated with humoral innate immune response in chicken
Symbol | ID | Name | Ch | Metabolic Pathway | Gene Function |
|---|---|---|---|---|---|
BLNK | 395733 | B cell linker | 6 | BCR | B-cell development |
CARD11 | 416476 | caspase recruitment domain family, member 11 | 14 | BCR, TCR, NFκB | NFκB activation |
CASP7 | 423901 | caspase 7, apoptosis-related cysteine peptidase | 6 | BCR, TNFα | Apoptosis |
CAT | 423600 | Catalase | 5 | NFκB | Regulation of NFκB activity |
CD59 | 423148 | CD59 molecule, complement regulatory protein | 5 | T cells | T cell activation, complement system inhibition |
CD7 | 417346 | T-cell antigen CD7 precursor | 18 | T cells | T cell activation, T and B cell interaction, component of mature T cells |
CD82 | 423172 | CD82 molecule | 5 | NFκB, p53 | Binding of proteins in cell membrane |
CIITA | 427676 | class II, major histcompability complex, transactivator | 14 | TLR, MHC | LRR binding, MHCII transcription activation |
CXCL12 | 395180 | chemokine (C-X-C motif) ligand 12 | 6 | IL | Leukocyte activation, T cell proliferation, chemotaxis |
FADD | 423146 | FAS (TNFRSF6)-associated via death domain | 5 | NFκB | Apoptosis, NFκB cascade activation, early development of T cells |
FAS | 395274 | TNF receptor superfamily, member 6 | 6 | TNFα, Fas, B and T cells | Ig production, immune response with (B cells) Homeostasis between B I T cells |
FGF10 | 395432 | fibroblast growth factor 10 | Z | NFκB, MAPK | TLR activation, inflammatory cytokine secretion (with APC) |
FGF8 | 396313 | fibroblast growth factor 8 | 6 | MAPK | MAPK cascade activation |
FOS | 396512 | v-fos FBJ murine osteosarcoma viral oncogene homolog | 5 | TLR, BCR, TCR, MAPK, JNK, IL | Synthesis of AP-1 transcription factor |
IGSF6 | 771906 | immunoglobulin superfamily, mem. 6 | 14 | B and T cells | Membrane receptor of T and B cells |
IL20RB | 768437 | interleukin 20 receptor beta | 14 | Jak-STAT, IL | T and B cells proliferation and differentiation |
IL21R | 416586 | interleukin 21 receptor | 14 | Jak-STAT, IL | T and B cells proliferation and differentiation |
IL31RA | 427140 | interleukin 31 receptor A | Z | MAPK, Jak-STAT, IL | MAPKKK cascade, cytokine and chemokine signal transduction, monocyte and macrophage differentiation |
IL4R | 416585 | interleukin 4 receptor | 14 | T cells, IL | Th2 lymhocyte differentation, cytokine receptor |
IL6ST | 395684 | interleukin 6 signal transducer | Z | IL | Fragment of cytokine receptor complex |
IL9R | 416587 | interleukin 9 receptor | 14 | Jak-STAT, IL | Jak and STAT activation, cytokine receptor |
JAK2 | 374199 | Janus kinase 2 | Z | Jak-STAT, IL | Cytokine signalling |
LITAF | 374125 | lipopolysaccharide induced TNF factor | 14 | TNFα | TNFα expression |
MAP2K3 | 416496 | Mitogen activated protein kinase kinase 3 | 14 | MAPK, TLR, JNK, Fc, p38, TNFα, Jak-STAT, TRAIL | MAPKKK cascade |
MAP2K4 | 417312 | Mitogen activated protein kinase kinase 4 | 18 | MAPK, TLR, Fas, JNK, Fc, TCR, Jak-STAT, TRAIL | MAP kinase activation, in response to different stimuli, survival signal for T cells |
MAP3K1 | 427144 | mitogen activated protein kinase kinase kinase 1 | Z | MAPK, TLR, Fas, JNK, Fc, p38, NFκB, TCR, BCR, INFγ, TRAIL, TNFα | Integration of enzyme fosforylation in response to different factors |
MAP3K 13 | 424876 | mitogen-activated protein kinase kinase kinase 13 | 9 | MAPK, JNK | Activation of different MAP kinases |
MAPK8 IP3 | 426986 | mitogen-activated protein kinase 8 interacting protein 3 | 14 | MAPK, JNK | MAPK and JNK integration |
NFKBIA | 396093 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 5 | TLR, BCR, TCR, NFκB | NFκB Inhibitor |
PDCD4 | 374191 | programmed cell death 4 (neoplastic transformation inhibitor) | 6 | JNK | Negative JNK regulation, expression of the gene under control of T cells |
RAG2 | 423165 | recombination activating gene 2 | 5 | B and T cells | B and T cells differentiation, gene conversion in Ig |
RBP4 | 396166 | retinol binding protein 4, plasma | 6 | B cells | Activation of Ig secretion |
SOCS1 | 416630 | supressor of cytokine sygnalling 1 | 14 | Jak-STAT, IL | Inhibition of cytokine secretion & Jak-STAT cascade |
TCF7L2 | 395508 | Transcription factor 7-like 2 | 6 | WNT | WNT signalling |
TGFB3 | 396438 | transforming growth factor, beta 3 | 5 | MAPK, TGFβ, GPCR | MAPK activation, growth factor activity |
TNFRSF13B | 770275 | TNF receptor superfamily, member 13B | 14 | AP-1, NFκB, TNF | Key role in humoral immune response |
TRAF6 | 423163 | TNF receptor-associated factor 6 | 5 | TNF, TLR, IL, NFκB, TCR | Signal transduction in many pathways, Th1 immune response, T cell activation |
TRAF7 | 416555 | TNF receptor-associated factor 7 | 14 | TNF | MAPKKK cascade activation |