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Figure 3 | BMC Proceedings

Figure 3

From: Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B. melitensis, S. enterica Typhimurium and M. avium paratuberculosis

Figure 3

MAPK pathway network model for bovine host infected with Salmonella enterica Typhimurium (STM). The model is trained and then used to score the pathway and individual genes. This figure is the MAPK pathway as a screen capture taken from BioSignatureDS™ user interface. This figure is a snapshot of the perturbed state of the MAPK pathway at 60 minutes post infection for the STM-Host condition. Mechanistic genes are encircled with an orange ring. In the pathway, genes aligned along the green vertical bar are typically receptor/membrane related, and those on the blue bar are nucleus related. Gene nodes with an attached “TF” subscript are transcription factors or transcription factor related. The arcs connecting genes are coded to indicate the correlation between connected genes. Brown arcs indicate positive correlation while turquoise arcs represent negative correlations, and the thickness of the arc indicating the magnitude of correlation. Arcs with an encircled number and arrow correspond to those arcs labeled accordingly in Table 1.

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