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Table 1 Polymorphic isoforms of porcine type I interferons (IFNs)

From: Porcine type I interferons: polymorphic sequences and activity against PRRSV

IFN polymorphic isoforms

Different from reference sequences1

NA → AA

Potential responsible mutations2

IFNα2-1

7 SNP 5 AA

L40-F, C109-R

IFNα2-2

5 SNP 3 AA

A127-V

IFNα3-1

5 SNP 4 AA

K145-E,

IFNα3-2

7 SNP 6 AA

L40-F

IFNα6-1

(Wild type)

 

IFNα6-2

4 SNP 1 AA

D101-N

IFNα8-1

8 SNP 5 AA

N17-D

IFNα8-2

7 SNP 4 AA

 

IFNα8μ

8 SNP 2 AA

T9-M, d(R46)

IFNα10-1

12 SNP 8 AA

F88-S

IFNα10-2

12 SNP 8 AA

K73-E

IFNα12-1

3 SNP

S158-N, P161-L

IFNα12-2

4 SNP 1 AA

L90-P, D101-N, A127-V, V174-A

IFNα12μ

10 SNP (ORF)

ORF shifted after 100 AA

IFNδ1-1

1 SNP 1 AA

T65-A

IFNδ1-2

2 SNP 1 AA

N91-T

IFNω5-1

3 SNP 1 AA

C52-R

IFNω5-2

1 SNP

 

IFNω5μ

6 SNP (ORF)

d(stop) and added C-17 AA

  1. 1.Reference sequences were extracted from genomic draft sequences by Sanger Institute Porcine Project Team at the Wellcome Trust Sanger Institute and can be obtained from http://www.ensembl.org/Sus_scrofa/index.html. NA, Nucleic acid; AA, amino acid; SNP, single nucleotide polymorphism; (ORF), shifted open reading frame. 2. Potential responsible mutations are defined as mutations at the protein levels in the predicted mature peptide region and those occurring only in the isoforms with altered antiviral activity. Amino acid residues are shown as single letter symbols, L40-F indicating the 40thleucine mutated to phenylalanine, for example. d(X) or d(stop), deletion of indicated residue X or stop codon.