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Figure 1 | BMC Proceedings

Figure 1

From: Digging into the extremes: a useful approach for the analysis of rare variants with continuous traits?

Figure 1

Power to detect genes with rare causal SNPs using different methods. Showing the power to detect (A) each of the 9 genes including causal SNPs for Q1 and (B) each of the 13 genes for Q2 for all methods used: linear regression (black dots); weighted sum (WS), Fisher’s exact test, and beta test on the categorized trait (top 10% versus bottom 10%) (red dots); and all three methods on the dichotomized trait (top 10% versus bottom 90%) (blue dots). Power was calculated as the percentage of nominally significant p-values using all 200 replicates.

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