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Table 1 Proportion of 200 replicates identifying causal variants in traits Q1 and Q2

From: Comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression

Trait

Gene

Variant

PoR for uncollapsed variants

PoR for collapsed variants

(MAF < 0.01 and nonsynonymous)

   

TR 10−2

TR 10−7

SLR 10−7

TR 10−2

TR 10−7

SLR 10−7

Q1

ARNT

C1S6533

0.245

0.005

0.045

0.31

0.02

0.045

 

KDR

C4S1877

0

0

0.255

0.16

0.005

0.055

  

C4S1884

0.16

0.015

0.065

0.2

0.01

0.065

  

C4S1889

0

0

0.255

0.025

0

0.01

 

FLT1

C13S431

0.475

0.095

0.12

0.495

0.08

0.12

  

C13S522

0.745

0.115

0.99

0.78

0.165

0.99

  

C13S523

1

0.72

1

1

0.72

1

  

C13S524

0.115

0.01

0.39

0.03

0

0.005

 

Average PoR

 

7.9 × 10−2

2.5 × 10−2

8.2 × 10−2

1.6 × 10−1

4.8 × 10−2

1.1 × 10−1

Q2

VNN1

C6S5380

0.42

0.01

0.03

0.415

0.025

0.03

 

Average PoR

 

2.2 × 10−2

6.3 × 10−4

4.9 × 10−4

7.2 × 10−2

2.7 × 10−3

1.8 × 10−3

  1. TR, tiled regression. SLR, simple linear regression. PoR, proportion of 200 replicates. For the tiled regression, 10−2 and 10−7 are the critical values; for the simple linear regression, 10−7 is the significance level.