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Table 1 Causal gene with tested p-value

From: A novel method to detect rare variants using both family and unrelated case-control data

Gene

p-value (Madsen and Browning method)

p-value (our method)

AKT3

0.173

1.0

BCL2L11

0.0555

1.0

ELAVL4

0.90

0.0283

HSP90AA1

0.737

8.63 × 10−6

NRAS

0.459

1.0

PIK3C2B

1.48 × 10−5

8.67 × 10−10

PIK3C3

0.796

1.0

PIK3R3

0.732

0.236

PRKCA

0.564

1.0

PRKCB1

0.684

0.236

PTK2

0.868

1.0

PTK2B

0.433

1.0

RRAS

0.480

1.0

SHC1

0.925

1.0

SOS2

0.465

1.0

  1. The causal genes of latent liability disease and their p-values found using Madsen and Browning’s method and our proposed method.