Table 1 Global productivity, Host cell Proteins, High Molecular Weight and Low Molecular Weight contents in perfusion processes compared to batch ones reached in Mobius® CellReady 3L bioreactor in addition to upstream cost to reach ATF™ mAb quantity, in perfusion processes compared to batch one in Mobius® CellReady Family
From: Evaluation of single-use bioreactors for perfusion processes
Batch mode | Fibra-Cel® technology | ATF™ technology | |
|---|---|---|---|
Final Titer | 100% | 121% | 290% |
Host Cell Proteins | 100% | 28% | 144% |
High Molecular Weight | 100% | 87% | 198% |
Low Molecular Weight | 100% | 68% | 107% |
Upstream cost at 3L GLP Scale | 100% | 108% | 47% |
Upstream cost at 50L GLP Scale | 100% | 175% | 84% |
Upstream cost at 200L GMP Scale | 100% | 134% | 47% |