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Figure 1 | BMC Proceedings

Figure 1

From: NIR-spectroscopy for bioprocess monitoring & control

Figure 1

Batch evolution models (BEM) based on NIR spectra. (Top): Batch trajectories from three batches based on the first principal component of NIR spectra. The golden batch trajectory is shown in green (mean value of all contributing batches) and the process limits are shown in red (three times the standard deviation of the three contributing batches). (Middle): Compared to the BEM other batches show deviations which can be assigned to contaminations (blue line) or low cell growth rate (black line). (Bottom): Batch trajectories from three batches based on the third principal component of NIR spectra. Compared to the BEM other batches show deviations like contaminations (blue and violet line) or early glucose limitation which led to an early drop of viability (black, yellow and violet line).

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