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Figure 1 | BMC Proceedings

Figure 1

From: Scale-up considerations for monoclonal antibody production process: an oxygen transfer flux approach

Figure 1

Cell culture process performance at 2 L, 10 L and 80 L scale. a) Impact of agitation speed on VCD and mAb titer at 2 L scale. b) Comparison of VCD, viability and mAb titer obtained in 2 L, 10 L and 80 L bioreactors. c) Comparison of osmolality, glucose and lactate profiles obtained in 2 L, 10 L and 80 L bioreactor. d) Online pH and dCO2 levels obtained in 2 L, 10 L and 80 L bioreactors.

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