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Table 1 Comparison of culture parameters at various temperatures

From: Improvement of production rate on recombinant CHO cells in two-stage culture

 

30 °C

33 °C

35 °C

37 °C

37 °C→33 °C

specific growth rate [h-1]

>0.0002

0.0072

0.0107

0.0136

-

q s CR1 [109 g cells-1 h-1]

0.0304

0.0416

0.0407

0.0446

-

final sCR1 [mg/mL] (a)

3.04

8.68

8.11

7.67

15.2

XS [106 cells/mL] (b)

0.223

0.788

1.09

1.15

1.20

(a)/(b)

13.6

11.0

7.43

6.68

12.7