Figure 1From: Full transcriptome analysis of Chinese Hamster Ovary cell lines producing a dynamic range of Coagulation Factor VIIIDepth of sequenced reads at every position of the FVIII gene. It is seen that the 3 non-producing clones transcribe 5'-truncated RNA species. This would explain the phenotype of no FVIII protein production but growth under MTX selection as the IRES element containing DHFR is still transcribed.Back to article page