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Figure 1 | BMC Proceedings

Figure 1

From: A robust RMCE system based on a CHO-DG44 platform enables efficient evaluation of complex biological drug candidates

Figure 1

A: RMCE Strategy for routine RMCE application in the selected CHO-DG44 RMCE host cell line. M = selection marker, haat = A1AT gene. B: GFP expression of cell populations derived from multiple RMCEs and selection formats. C: RMCE with a monoclonal antibody. Fed batch of the direct RCME derived population and three individual RMCE clones derived from original RMCE population. D: RMCE with two variants of a soluble receptor-Fc fusion protein. Exemplary fed batch process for the both RMCE derived Fc fusion protein variants. E: Timescale of routine RMCE Application.

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BMC Proceedings

ISSN: 1753-6561

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