Skip to main content
Figure 1 | BMC Proceedings

Figure 1

From: Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing

Figure 1

14-day tissue performance of the micro-bioreactor culture compared to static control Cell functionality shown by immunostaining of (A) phase I enzyme CYP450 3A4 (red) and CYP450 7A1 (green), (B) collagen I (red) and vimentin (green), (C) MRP2, an ABC transporter located at the apical membrane, (green) and (D) tight junction protein ZO-1 (red). Cell viability shown by TUNEL KI67 staining of (E) liver equivalents cultivated for 28 days in the micro-bioreactor and (F) liver equivalents cultivated for 28 days under static conditions. Nuclei are stained with hoechst 33342. Scale bar: 100 μm.

Back to article page