Figure 4

Distance distributions of diverse and self-similar annotation groups. Each part displays histograms of FATCAT alignment distance between members of a group and all other structures (bottom, "vs. PDB25") and between group members only (top, "vs. self"). The left two groups for each classification level are considered structurally diverse, while the right two are considered structurally self-similar. SCOP superfamily, SCOP family and CATH superfamily ("H") (Parts (A)-(C) respectively) were selected because they are based on shared function or evolutionary origin rather than structure alone.