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Table 3 Pathway analysis for the best three five-marker panels.

From: A neural network approach to multi-biomarker panel discovery by high-throughput plasma proteomics profiling of breast cancer

PathwayID

PathwayName

Molecule

hsa04610

Complement and coagulation cascades

FGG;SERPING1;C4BPA;CFI

h_intrinsicPathway

Intrinsic Prothrombin Activation Pathway

FGG;SERPING1

140877

Formation of Fibrin Clot (Clotting Cascade)

FGG;SERPING1

114608

Platelet degranulation

SERPING1;FGG

76005

Response to elevated platelet cytosolic Ca2+

SERPING1;FGG

hsa05133

Pertussis

SERPING1;C4BPA

hsa05150

Staphylococcus aureus infection

FGG;CFI

354194

GRB2:SOS provides linkage to MAPK signaling for Intergrins

FGG

140875

Common Pathway

FGG

76002

Platelet activation, signaling and aggregation

FGG;SERPING1

372708

p130Cas linkage to MAPK signaling for integrins

FGG

h_extrinsicPathway

Extrinsic Prothrombin Activation Pathway

FGG

h_fibrinolysisPathway

Fibrinolysis Pathway

FGG

140837

Intrinsic Pathway

SERPING1

h_amiPathway

Acute Myocardial Infarction

FGG

200138

Beta2 integrin cell surface interactions

FGG

200204

Ephrin B reverse signalling

FGG

200037

CD40/CD40L signalling

C4BPA

354192

Integrin alphaIIb beta3 signaling

FGG

76009

Platelet Aggregation (Plug Formation)

FGG

200043

Beta3 integrin cell surface interactions

FGG

200061

Regulation of RhoA activity

HP

200139

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalling

FGG

200146

IL6-mediated signaling events

FGG

hsa05143

African trypanosomiasis

HP

432722

Golgi Associated Vesicle Biogenesis

CNO

109582

Hemostasis

FGG;SERPING1

199992

trans-Golgi Network Vesicle Budding

CNO

421837

Clathrin derived vesicle budding

CNO

200016

Beta1 integrin cell surface interactions

FGG