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Table 1 Empirical power and type I error at α = 0.05 for diastolic blood pressure and systolic blood pressure phenotypes

From: Rare variant analysis of blood pressure phenotypes in the Genetic Analysis Workshop 18 whole genome sequencing data using sequence kernel association test

Phenotype

DBP

SBP

SNPs

All

Rare

All

Rare

Weight

Equal

M-B

Default

Equal

M-B

Default

Equal

M-B

Default

Equal

M-B

Default

Type I Error

0.047

0.043

0.043

0.044

0.042

0.043

0.048

0.048

0.049

0.048

0.050

0.049

Power

0.053

0.050

0.048

0.048

0.050

0.048

0.054

0.053

0.053

0.049

0.052

0.052

  1. Bolded text indicates the highest power across 6 analysis options for each phenotype.
  2. DBP, diastolic blood pressure; M-B, Madsen-Browning; SBP, systolic blood pressure; SNP, single-nucleotide polymorphism.
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BMC Proceedings

ISSN: 1753-6561

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