Table 1 Estimates for the effects of the CRVs in individual genes with 3 weighting schemes for variants with MAF ≤0.01
From: Identification of rare variants for hypertension with incorporation of linkage information
Without weighting | Exponential weighting | Cumulative weighting | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Gene* | LOD score | Estimate (SE) | pValue | FDR | Estimate (SE) | pValue | FDR | Estimate (SE) | pValue | FDR | Previous hits† |
GK5 (1) | 7.00 | −0.013 (0.023) | 0.57 | 0.75 | −0.013 (0.023) | 0.57 | 0.69 | −0.013 (0.023) | 0.57 | 0.75 | L |
ATR (10) | 7.00 | 0.055 (0.038) | 0.15 | 0.28 | 0.057 (0.036) | 0.12 | 0.23 | 0.055 (0.038) | 0.15 | 0.28 | L |
DOCK3 (51) | 3.87-6.35 | 0.035 (0.013) | 0.0090 | 0.031 | 0.0089 (0.0043) | 0.040 | 0.12 | 0.025 (0.0098) | 0.013 | 0.044 | |
C3orf26 (24) | 5.09 | 0.023 (0.046) | 0.62 | 0.75 | −0.050 (0.056) | 0.37 | 0.57 | 0.022 (0.048) | 0.64 | 0.78 | L |
FILIP1L (20) | 5.09 | −0.048 (0.053) | 0.37 | 0.57 | −0.092 (0.065) | 0.16 | 0.27 | −0.049 (0.058) | 0.40 | 0.62 | L |
ILDR1 (1) | 5.96 | −0.032 (0.12) | 0.79 | 0.84 | −0.032 (0.12) | 0.79 | 0.90 | −0.032 (0.12) | 0.79 | 0.86 | |
ARMC8 (6) | 5.16 | −0.13 (0.031) | 2.27E-5 | 0.00013 | −0.12 (0.028) | 1.29E-5 | 7.31E-5 | −0.13 (0.031) | 2.24E-5 | 0.00013 | L |
NME9 (5) | 5.16 | −0.085 (0.049) | 0.081 | 0.20 | −0.083 (0.048) | 0.081 | 0.20 | −0.085 (0.049) | 0.081 | 0.20 | L |
FAIM (2) | 5.16 | −0.13 (0.090) | 0.14 | 0.28 | −0.14 (0.089) | 0.11 | 0.23 | −0.13 (0.090) | 0.14 | 0.28 | L |
KCNAB1 (16) | 3.05-5.33 | 0.054 (0.016) | 0.00058 | 0.0025 | 0.065 (0.020) | 0.0011 | 0.0047 | 0.060 (0.018) | 0.00077 | 0.0033 | LG |
MYRIP (4) | 4.32 | −0.22 (0.050) | 1.39E-5 | 0.00012 | −0.20 (0.044) | 6.29E-6 | 5.35E-5 | −0.19 (0.042) | 5.79E-6 | 4.92E-5 | |
ZNF621 (1) | 4.32 | −0.44 (0.021) | <1.0E-30 | <1.0E-30 | −0.44 (0.021) | <1.0E-30 | <1.0E-30 | −0.44 (0.021) | <1.0E-30 | <1.0E-30 | |
GBE1 (2) | 4.36 | −0.32 (0.16) | 0.039 | 0.11 | −0.32 (0.16) | 0.041 | 0.12 | −0.32 (0.16) | 0.039 | 0.11 | LG |
CHCHD6 (24) | 4.14 | 0.00037 (0.013) | 0.98 | 0.98 | 0.0018 (0.011) | 0.88 | 0.90 | 0.00093 (0.013) | 0.95 | 0.95 | G |
STAG1 (23) | 4.32 | 0.011 (0.042) | 0.79 | 0.84 | 0.0047 (0.037) | 0.90 | 0.90 | 0.010 (0.041) | 0.81 | 0.86 | L |
CLSTN2 (20) | 4.52 | 0.027 (0.027) | 0.30 | 0.51 | 0.015 (0.023) | 0.51 | 0.69 | 0.026 (0.026) | 0.32 | 0.54 | L |
WDR49 (11) | 4.16 | 0.043 (0.063) | 0.49 | 0.69 | 0.024 (0.043) | 0.57 | 0.69 | 0.031 (0.046) | 0.50 | 0.71 | L |