Next-generation linkage and association methods applied to hypertension: a multifaceted approach to the analysis of sequence data

Table 1 Characteristics of sequence variants identified by NGLA methods

Variant	Minor allele	MAF	PPLD	SNP	Intronic OSBPL10	Comment
3_30813267	G	0.3790	0.04	Y	N
3_30833347	T	0.2115	0.04	Y	N
3_30836121	A	0.2196	0.04	Y	N	Is also 1 of 65,519 GWAS SNPs
3_30836281	A	0.2169	0.04	Y	N
3_30836986	T	0.2196	0.04	Y	N
3_30837454	G	0.2246	0.04	Y	N
3_30839168	G	0.2159	0.04	Y	N
3_31367917	A	0.0017	0.04	N	N	Appears only in families 4 &15
3_31590155	A	0.0017	0.04	N	Y	Appears only in families 4 &15
3_31688599	A	0.0017	0.04	Y	Y	Appears only in families 4 &15
3_31773725	C	0.0017	0.04	N	Y	Appears only in families 4 &15
3_31907631	A	0.0729	0.14	Y	Y	AKA rs7624739

MAF, minor allele frequency.
Sequence variants 3_31367917,3_31590155,3_31688599, and 3_31773725 (in bold) form a rare 4-site haplotype that strongly segregates with low SBP.

ISSN: 1753-6561