Figure 2
From: Higher criticism approach to detect rare variants using whole genome sequencing data
Power of higher criticism (HC) for detecting all true windows on chromosome 3. (A) Comparison among variant-grouping strategies by fixed windows (10, 100, and 500 kbps) and genes. (B) Comparison among minor allele frequency thresholds for rare variants and weighting strategies for collapsing rare variants. (C) Comparison among three association tests. MB , Madsen-Browning; minP , minimum p-value method; SKAT , sequence kernel association test.