Figure 1

p-Values from linkage and association tests. Here we present the chromosome locations of the 500 most significant single-nucleotide polymorphisms (SNPs) on chromosome 3 identified by each method and their corresponding -log p-values. The triangles are the 500 most significant SNPs identified by the genome-wide association studies (GWAS) score test using unrelated individuals; the crosses are those identified by FBAT, and the plusses are those identified by the gene-dropping test. The solid curve shows the -log p-values from the linkage test at 449 evenly spaced SNPs (by comparing the linkage component of the gene-dropping test statistic with its Monte Carlo null distribution from gene dropping). Solid vertical lines indicate the positions of truly influential SNPs on chromosome 3.