Figure 1

Gene-based ROC curve. Gene-based false-positive and true-positive rates plotted when employing a 50% and 90% lasso proportion on each trait (SBP and DBP) at exam 1 over the 200 simulation replicates. These plots are for models including all variants. Rates are defined as the number of distinct noncausal genes (genes containing no causal variants) in the final model divided by the total number of noncausal genes (False-positive rate; x-axis) and the number of distinct causal genes (genes with at least 1 causal variant) in the final model divided by the number of true causal genes (True-positive rate; y-axis). There are 27 (22) causal genes for DBP (SBP) and 1138 (1143) noncausal genes. Random "jitter" has been added to the y-axis because many replicates resulted in the same number of causal genes and a loess line with confidence bands illustrates a general trend. Results when using the 5% MAF restriction are similar, but with higher rates as a result of the decreased number of genes.