BMC Proceedings

Table 1 Empirical powers for DBP causal variants.

From: On family-based genome-wide association studies with large pedigrees: observations and recommendations

	Characteristics				No correction		Bonferroni correction
SNP	Gene	MAF	Effect Size	Heritability	MGA	FBAT	MGA	FBAT	FBAT-VS
rs304079	SUMF1	0.4828	0.0895	0.00005	0.015	0.010	0	0	0
rs373572	RAD18	0.3707	0.0002	0	0.050	0.015	0	0	0
rs1800734	MLH1	0.3190	−0.1142	0.00007	0.005	0.060	0	0	0
rs2020873	MLH1	0.0135	−0.4753	0.00005	0.035	0*	0	0*	0*
rs11711953	MAP4	0.0261	−6.2235	0.02290	1.000	0.310	0.995	0.000	0.370
rs1131356	FLNB	0.4955	0.3875	0.00085	0.180	0.090	0	0	0
rs3772985	DNASE1L3	0.1983	−0.0795	0.00003	0.015	0.015	0	0	0
rs12491947	DNASE1L3	0.0766	0.0005	0	0.020	0	0	0	0
rs9815775	DNASE1L3	0.3103	0.037	0.00001	0.015	0.060	0	0	0
rs2322142	PROK2	0.4234	−0.0678	0.00003	0.015	0.015	0	0	0
rs6438503	B4GALT4	0.1595	−0.1248	0.00004	0.020	0.025	0	0	0
rs6805930	B4GALT4	0.0496	0.1855	0.00004	0.055	0.005	0	0	0
rs4679394	MUC13	0.1897	−0.0891	0.00003	0.035	0.015	0	0	0
rs9814557	PPP2R3A	0.1293	0.0057	0	0.020	0.005	0	0	0
rs9826032	PPP2R3A	0.0135	0.0006	0	0.055	0*	0	0*	0*
rs4683602	ZBTB38	0.2716	0.0725	0.00003	0.220	0.105	0	0	0
rs16851435	ZBTB38	0.2432	−0.0041	0	0.405	0.140	0	0	0

Results from 200 Genetic Analysis Workshop (GAW) simulations for MGA, FBAT and FBAT-VS (the FBAT top 10 screening approach). SNPs conferring at least 20% power for any method are indicated in bold. The gene, minor allele frequency (MAF; estimated from founders), effect size, and heritability are provided. Results without multiple testing correction are listed under "No correction." Methods with a genome-wide correction are under "Bonferroni correction." Entries marked with an asterisk (*) were not tested with FBAT methods because of a lack of informative families.

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ISSN: 1753-6561

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