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Table 2 Candidate gene analysis results

From: Rare genetic variant analysis on blood pressure in related samples

Previous GWAS results

Rare-variant analysis

Common-variant analysis

SNP

Chr

Position

Gene

Gene position

Trait

pvalue

N SNPs

famBT

pvalue

famSKAT

pvalue

GWA position

GWA pvalue

rs880315*

1

10796866

CASZ1

10696661-10856707

SBP

2.1 × 10−7

771

0.563

0.804

10798489

0.0099

rs17367504§

1

11862778

MTHFR

11845787-11866160

SBP

2.0 × 10−13

97

0.665

0.744

11860120

0.0477

rs9815354*

3

41912651

ULK4

41288090-42003660

DBP

7.8 × 10−7

3104

0.233

0.344

41951111

0.0003

rs381815*

11

16902268

PLEKHA7

16809207-17035963

SBP

5.8 × 10−7

851

0.262

0.458

16842787

0.0088

rs11024074*

11

16917219

PLEKHA7

16809207-17035963

DBP

2.8 × 10−7

851

0.995

0.776

17015044

0.0093

rs1378942§

15

75078343

CSK

75074425-75095539

DBP

1.0 × 10−23

91

0.154

0.174

75095157

0.1101

rs6495122*

15

75125645

CSK-ULK3

75128459-75135552

DBP

8.0 × 10−7

21

0.155

0.712

75130093

0.0709

rs12946454§

17

43208121

PLCD3

43189008-43209891

SBP

1.0 × 10−8

101

0.013

0.490

43202188

0.0449

rs16948048§

17

47440466

ZNF652

47366568-47439835

DBP

5.0 × 10−9

263

0.909

0.611

47411575

0.076

  1. *SNP from CHARGE [2], with p value <5.0 × 10−6
  2. §SNP from GBPGEN [1], with p value <5.0 × 10−8. Previous GWAS positions were updated to NCBI build 37.
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BMC Proceedings

ISSN: 1753-6561

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