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Table 1 The power and false-positive rate (FPR) of the 4 methods in simulated data

From: Adjustment of familial relatedness in association test for rare variants

Gene

 

UNI

UNI-ADJ

SKAT

SKAT-ADJ

 

# of NS variants

Power

FPR

Power

FPR

Power

FPR

Power

FPR

MAP4

8

1

0.12

1

0.04

1

0.13

1

0.03

TNN

20

0.9

0.225

0.74

0.055

0.895

0.38

0.825

0.04

LEPR

6

0.915

0.125

0.895

0.05

0.22

0.085

0.73

0.04

FLT3

4

0.66

0.105

0.3

0.045

0.33

0.135

0.305

0.07

FLNB

13

0.44

0.14

0.165

0.03

0.08

0.17

0.515

0.035

ZNF443

9

0.070

0.155

0.035

0.030

0.150

0.075

0.050

0.075

GSN

6

0.265

0.155

0.130

0.070

0.030

0.065

0.385

0.065

  1. A significance level of 0.05 was used to calculate both power and FPR.
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BMC Proceedings

ISSN: 1753-6561

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