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Table 1 Estimated effects on the simulated SBP_1 trait for known causal genes

From: A variance component-based gene burden test

Gene

Strategy

 

Intragenic

   

Nonsyn

   
 

h2r

h2r_p

geff

geff_p

h2r

h2r_p

geff

geff_p

MAP4

0.17

3.90 × 10−6

0.10955

7.20 × 10−6

0.18

7.00 × 10−7

0.10382

1.00 × 10−7

LEPR

0.26

4.16 × 10−8

0.04702

6.52 × 10−3

0.31

2.28 × 10−10

0.01147

1.71 × 10−1

LRP8

0.28

6.97 × 10−9

0.03575

6.55 × 10−3

0.32

3.44 × 10−11

0

1

GTF2IRD1

0.29

4.19 × 10−9

0.01755

9.24 × 10−2

0.32

3.44 × 10−11

0

1

TNN

0.30

9.51 × 10−10

0.01615

9.29 × 10−2

0.27

7.20 × 10−9

0.03433

1.26 × 10−3

FLT3

0.30

8.37 × 10−10

0.00906

1.59 × 10−1

0.32

3.44 × 10−11

0

1

CABP2

0.32

4.12 × 10−11

0.00037

4.76 × 10−1

0.32

3.44 × 10−11

0

1

ABTB1

0.32

3.44 × 10−11

0

1

0.21

4.01 × 10−11

0.17969

1.90 × 10−1

GAB2

0.32

3.44 × 10−11

0

1

0.32

3.44 × 10−11

0

1

GSN

0.32

3.44 × 10−11

0

1

0.32

3.44 × 10−11

0

1

KRTAP11-1

0.32

3.44 × 10−11

0

1

0.32

3.44 × 10−11

0

1

PSMD5

0.32

3.44 × 10−11

0

1

0.30

9.46 × 10−11

0.00949

1.25 × 10−1

  1. geff, Gene-specific effect estimate ( h g e f f 2 ); geff_p, significance of the gene-specific effect estimate; h2r, trait heritability estimate ( h r 2 ); h2r_p, significance of the trait heritability estimate.
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BMC Proceedings

ISSN: 1753-6561

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