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Table 2 Top 10 most significant results for genes in a combined sample of 100 random and 12 causal genes

From: A variance component-based gene burden test

Rank

Strategy

 

Intragenic

    

Nonsyn

    
 

Gene

h2r

h2r_p

geff

geff_p

Gene

h2r

h2r_p

geff

geff_p

1

MAP4*

0.17

3.90 × 10−6

0.10955

7.20 × 10−6

MAP4*

0.18

7.00 × 10−7

0.10382

1.00 × 10−7

2

OR9A4

0.18

6.16 × 10−11

0.20337

4.64 × 10−3

TNN*

0.27

7.20 × 10−9

0.03433

1.26 × 10−3

3

LEPR*

0.26

4.16 × 10−8

0.04702

6.52 × 10−3

LSM12

0.15

3.40 × 10−11

0.26452

4.96 × 10−3

4

LRP8*

0.28

6.97 × 10−9

0.03575

6.55 × 10−3

NAT6

0.30

3.20 × 10−11

0.02515

1.16 × 10−2

5

NAT6

0.28

1.12 × 10−10

0.03592

8.39 × 10−3

AK123654

0.15

2.27 × 10−10

0.25783

1.37 × 10−2

6

CCDC169-SOHLH2

0.28

1.05 × 10−8

0.03547

2.25 × 10−2

OR2T27

0.28

1.05 × 10−10

0.04869

1.46 × 10−2

7

OR2T27

0.30

1.07 × 10−10

0.03072

4.20 × 10−2

HSPA9

0.15

8.69 × 10−12

0.26952

5.04 × 10−2

8

CCDC169

0.31

8.85 × 10−10

0.01913

4.53 × 10−2

LOC389493

0.21

1.52 × 10−10

0.16663

5.12 × 10−2

9

GNG3

0.18

1.85 × 10−10

0.20838

5.94 × 10−2

SRD5A1

0.32

2.25 × 10−11

0.01056

1.12 × 10−1

10

GAS7

0.28

1.91 × 10−8

0.03356

6.07 × 10−2

PSMD5*

0.30

9.46 × 10−11

0.00949

1.25 × 10−1

  1. geff, Gene-specific effect estimate ( h g e f f 2 ); geff_p, significance of the gene-specific effect estimate; h2r, trait heritability estimate ( h r 2 ); h2r_p, significance of the trait heritability estimate.
  2. *Known causal gene for SBP_1 in the simulated data set.
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BMC Proceedings

ISSN: 1753-6561

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