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Table 1 C-Alpha test results for markers in genes versus markers not in genes

From: Identifying rare variants associated with hypertension using the C-alpha test

 

Markers in genes

Markers not in genes

Window

Marker

pValue*

# RVs tested

C-alpha statistic

Permuted pvalue†

Marker

pValue*

# RVs tested

C-alpha statistic

Permuted pvalue†

1 kb

35751033

 

5

−31.83

0.090

  

13

1.91

0.008

5 kb

(gene ID: 51185)

0.00064

27

−100.25

0.276

5020216

0.00141

50

−0.11

0.415

25 kb

  

154

−939.73

0.629

  

127

−35.27

0.935

1 kb

212007

 

6

1.29

0.207

  

1

n/a

n/a

5 kb

(gene ID: 2272)

0.00174

20

−2.14

0.437

3953247

0.00158

9

−33.10

0.091

25 kb

  

101

−27.57

0.485

  

53

−23.10

0.245

1 kb

262976

 

0

n/a

n/a

  

4

1.94

<0.001

5 kb

(gene ID: 55689)

0.00214

4

1.86

0.070

11719665

0.00173

23

16.35

0.037

25 kb

  

34

10.96

0.002

  

64

23.23

0.041

1 kb

53856668

 

7

−0.42

0.367

  

4

−2.22

0.407

5 kb

(gene ID: 2272)

0.00192

22

−2.80

0.507

4553960

0.00186

10

−4.37

0.440

25 kb

  

104

−62.61

0.329

  

47

−1.37

0.009

1 kb

1464118

 

1

n/a

n/a

  

2

−6.40

0.227

5 kb

(gene ID: 8626)

0.00220

3

−1.28

0.891

34366649

0.00222

9

−5.46

0.161

25 kb

  

27

−25.29

0.658

  

15

36.97

0.030

  1. n/a, Not available.
  2. * From single marker association test.
  3. †Based on 1000 permutations using biased urn method. Highlighted p values are significant at an alpha of 0.05.
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BMC Proceedings

ISSN: 1753-6561

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