Evaluation of estimated genetic values and their application to genome-wide investigation of systolic blood pressure

Table 2 Significant results for GWA of EGVs and SBP by gene.

Gene	Chr	SBP	EGV_ped	EGV_snp	EGV_seq
LEPR	1	7	4	6	4
LRP8	1	6	0	8	5
NEXN	1	1	1	2	1
BTD	3	16	16	22	20
DNASE1L3	3	100	95	100	99
MAP4	3	100	95	100	99
SUMF1	3	33	14	34	39
MTRR	5	3	0	3	4
RHOD	11	2	0	1	1
TCIRG1	11	2	1	1	1
CYP1A2	15	0	0	1	0
C1QBP	17	0	1	0	1
KRT23	17	0	1	0	1
RAI1	17	0	1	0	1
SAT2	17	0	0	1	1
COL5A3	19	0	1	1	0

For each gene contributing to simulated SBP, the table lists the number of replicates (out of 100) in which at least one significant association was found. Variants in 24 additional genes have small effects on SBP but were never detected and were omitted from the table. Due to extended linkage disequilibrium, more than one gene may be tagged by a single variant; in particular, the associations in DNASE1L3 are likely due to strong LD with major causative gene MAP4.

ISSN: 1753-6561