Figure 1

Quantile-quantile plots of -log10 ( p -values) based on Fisher's statistic for all genes with 2 or more rare variants (reduced) in real data. (A) Coding (reduced). (B) Protein change (reduced). (C) Protein damage (reduced). See Table 1 for detailed variant annotation and binning strategies A to C. The p-values were obtained using the parametric bootstrap method as described in the text for hypertension status.