Figure 2

Results of pedigree genome-wide association sequencing for testing traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and Q1 in simulation replicate SIMPHEN.1 on the 1,213,657 single-nucleotide polymorphisms on chromosome 3 and 849 individuals. Top: Run times on a standard laptop. Bottom: Manhattan plot (left) and QQ plot (right) for the traits $\left(DB{P}_1,DB{P}_2,DB{P}_3\right)$. The horizontal line represents the genome-wide significance level. Plots for SBP and Q1 are similar and are omitted here.