Entropy-based method for assessing the influence of genetic markers and covariates on hypertension: application to Genetic Analysis Workshop 18 data

Table 1 Single-nucleotide polymorphisms in chromosome 9 that are sensitive to the covariates

	No-Attr	Sex		Smoke		Age		Ped		All-Attr
ID	BE	BE	CE	BE	CE	BE	CE	BE	CE	BE
rs7030214	0.667	0.663	0.982	0.659	0.991	0.567	0.943	0.587	0.295	0.320
rs4962043	0.668	0.665	0.999	0.662	0.999	0.580	0.987	0.593	0.295	0.328
rs6833	0.670	0.667	0.999	0.662	0.991	0.579	0.994	0.597	0.308	0.341
rs489504	0.666	0.657	0.964	0.659	0.958	0.577	0.987	0.597	0.300	0.334
rs3118667	0.665	0.661	0.994	0.659	0.997	0.579	0.993	0.599	0.295	0.353
rs3094375	0.669	0.667	0.999	0.662	0.990	0.581	0.996	0.600	0.294	0.348
rs1752337	0.669	0.663	0.996	0.663	0.992	0.575	0.979	0.601	0.291	0.308
rs652600	0.663	0.661	0.999	0.658	0.996	0.578	0.999	0.604	0.292	0.354
rs3124768	0.668	0.665	0.996	0.662	0.999	0.581	0.996	0.604	0.296	0.358
rs7867300	0.666	0.663	0.999	0.658	0.999	0.581	0.999	0.605	0.292	0.343
rs4877972	0.668	0.665	0.995	0.661	0.998	0.578	0.997	0.605	0.302	0.341
rs10781268	0.669	0.664	0.983	0.659	0.984	0.579	0.997	0.606	0.301	0.342
rs10811664	0.666	0.662	0.999	0.657	0.985	0.573	0.979	0.609	0.309	0.337
rs774227	0.668	0.663	0.960	0.661	0.999	0.574	0.999	0.619	0.293	0.359
rs557749	0.669	0.662	0.999	0.658	0.983	0.576	0.995	0.619	0.306	0.337
rs2422493	0.669	0.665	0.997	0.661	0.999	0.579	0.998	0.611	0.300	0.339
rs2184026	0.669	0.664	0.997	0.661	0.952	0.574	0.998	0.611	0.295	0.346

Note: BE is the block entropy; CE is the entropy for consistency. These 17 SNPs are among the 230 loci associated with hypertension that were also found by other researchers in the literature.

ISSN: 1753-6561