Table 2 Predictions of harmful mutations: 22 mutations identified as possibly causing damage to protein function using our automatic GA-based strategy.
Mutation | Avg. degree | Avg. betweenness | Avg. closeness (E-04) | Avg. accessibility |
|---|---|---|---|---|
I20A | 8.45 | 728.61 | 8.2 | 3.12 |
R26A | 6.76 | 236.21 | 7.69 | 33.79 |
Y49T | 6.8 | 227.64 | 7.68 | 23.21 |
S50A | 9.26 | 565.23 | 8.52 | 0.33 |
L53A | 6.76 | 138.71 | 7.45 | 36.94 |
K56G | 6.87 | 198.56 | 7.64 | 16.32 |
V59I | 7.63 | 537.69 | 8.49 | 5.7 |
T60K | 5.25 | 455.12 | 9.01 | 25.92 |
A66C | 7.12 | 1016.93 | 9.32 | 3.35 |
V80P | 9.2 | 719.95 | 8.77 | 1.19 |
W90Y | 6.96 | 1275.57 | 10.24 | 6.37 |
F115H | 6.48 | 416.05 | 8.57 | 22.09 |
Q119H | 6.21 | 165.8 | 8.22 | 27.2 |
G122K | 5.22 | 485.78 | 9.66 | 16.62 |
L147T | 9.48 | 808.43 | 9.23 | 0.47 |
V150L | 10.96 | 1109.65 | 9.48 | 0.67 |
E153G | 5.91 | 120.75 | 7.98 | 40.56 |
L204V | 9.26 | 1076.06 | 9.87 | 3.06 |
N213K | 5.72 | 265.96 | 8.09 | 37.79 |
G214P | 4.09 | 108.98 | 7.57 | 31.33 |
V226I | 9.31 | 787.96 | 9.6 | 1.76 |
V241L | 7.29 | 518.77 | 8.31 | 16.84 |