Table 1 Formulation and stability: Fab, IgG A and IgG B were dispersed and analyzed via SE-HPLC comparing monomer content before and after dispersion (n = 3, ± SD).
From: Protein aerosol for intranasal nose to brain (N2B) delivery
Formulation 1 | PBS | |||
|---|---|---|---|---|
Constructs | undispersed | dispersed | undispersed | dispersed |
Fab | 103.21 ± 3.62 | 90.27 ± 6.87 (ns) | 100.00 ± 0.53 | 77.86 ± 2.44 (**) |
IgG A | 103.17 ± 0.12 | 101.27 ± 2.79 (ns) | 100.00 ± 0.28 | 86.92 ± 2.99 (**) |
IgG B | 92.72 ± 4.51 | 74.88 ± 5.15 (**) | 100.00 ± 3.09 | 77.15 ± 4.12 (***) |