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Table 1 Formulation and stability: Fab, IgG A and IgG B were dispersed and analyzed via SE-HPLC comparing monomer content before and after dispersion (n = 3, ± SD).

From: Protein aerosol for intranasal nose to brain (N2B) delivery

  Formulation 1 PBS
Constructs undispersed dispersed undispersed dispersed
Fab 103.21 ± 3.62 90.27 ± 6.87 (ns) 100.00 ± 0.53 77.86 ± 2.44 (**)
IgG A 103.17 ± 0.12 101.27 ± 2.79 (ns) 100.00 ± 0.28 86.92 ± 2.99 (**)
IgG B 92.72 ± 4.51 74.88 ± 5.15 (**) 100.00 ± 3.09 77.15 ± 4.12 (***)
  1. For statistical analysis unpaired two-tailed t-Test was applied to compare undispersed with dispersed samples for each formulation (**p<0.01, ***p<0.001).