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Table 1 Microorganism retention testing usingViresolve® Barrier filter.

From: Protection of bioreactor culture from virus contamination by use of a virus barrier filter

Type

Organism

Description

TypicalLog Reduction Value

Viruses

Minute Virus of Mice (MVM)

Model parvovirus, reported contaminant of manufacturing operations, target organism

4.8

 

Phi-X174

Model bacteriophage of similar size to parvovirus, used as surrogate

6.0

 

XentropicMurineLeukemia Virus (xMuLV)

Model retrovirus

>5.3

Bacteria

Brevundimonasdiminuta

Standard model bacteria for ASTM sterilizing grade designation

>8.0

 

Leptonemaillini

Model spirochete bacteria, difficult to retain on sterilizing grade filters

>8.0

Mycoplasma

Acholeplasmalaidlawii

Standard model mycoplasma, pleomorphic, retained by 0.1 µm filters

>8.0

 

Mycoplasma orale

Model mycoplasma, small and pleomorphic, difficult to retain on 0.1 µm filters

>8.0