From: Protection of bioreactor culture from virus contamination by use of a virus barrier filter
Type | Organism | Description | TypicalLog Reduction Value |
---|---|---|---|
Viruses | Minute Virus of Mice (MVM) | Model parvovirus, reported contaminant of manufacturing operations, target organism | 4.8 |
 | Phi-X174 | Model bacteriophage of similar size to parvovirus, used as surrogate | 6.0 |
 | XentropicMurineLeukemia Virus (xMuLV) | Model retrovirus | >5.3 |
Bacteria | Brevundimonasdiminuta | Standard model bacteria for ASTM sterilizing grade designation | >8.0 |
 | Leptonemaillini | Model spirochete bacteria, difficult to retain on sterilizing grade filters | >8.0 |
Mycoplasma | Acholeplasmalaidlawii | Standard model mycoplasma, pleomorphic, retained by 0.1 µm filters | >8.0 |
 | Mycoplasma orale | Model mycoplasma, small and pleomorphic, difficult to retain on 0.1 µm filters | >8.0 |