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Table 1 Microorganism retention testing usingViresolve® Barrier filter.

From: Protection of bioreactor culture from virus contamination by use of a virus barrier filter

Type Organism Description TypicalLog Reduction Value
Viruses Minute Virus of Mice (MVM) Model parvovirus, reported contaminant of manufacturing operations, target organism 4.8
  Phi-X174 Model bacteriophage of similar size to parvovirus, used as surrogate 6.0
  XentropicMurineLeukemia Virus (xMuLV) Model retrovirus >5.3
Bacteria Brevundimonasdiminuta Standard model bacteria for ASTM sterilizing grade designation >8.0
  Leptonemaillini Model spirochete bacteria, difficult to retain on sterilizing grade filters >8.0
Mycoplasma Acholeplasmalaidlawii Standard model mycoplasma, pleomorphic, retained by 0.1 µm filters >8.0
  Mycoplasma orale Model mycoplasma, small and pleomorphic, difficult to retain on 0.1 µm filters >8.0