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Table 4 Independent eQTL SNP associations by sequential conditioning using p <0.05

From: Genetic complexity at expression quantitative trait loci

Gene

 

Enumeration of independent signals by association software

FaST-LMM

SOLAR-MGA

# SNPs conditioned on

# Significant SNPs

Minimum p value

# Significant SNPs

Minimum p value

TIMM10

0

25

3e-68

24

2e-66

1

23

2e-87

23

9.9e-86

2

10

5e-07

10

2e-07

3

2

0.03

1

0.05

4

1

0.04

–

–

LR8

0

67

4e-86

65

9e-83

1

39

2e-24

55

2e-22

2

47

1-11

63

4e-12

3

46

0.0001

41

0.0002

4

37

0.0001

39

0.0001

5

40

0.0003

41

0.0002

6

23

0.0004

22

0.0001

7

14

0.00002

17

0.005

8

14

0.003

8

0.01

9*

8

0.002

8

0.02

  1. *Six additional independent signals using SOLAR-MGA (0.019 < p <0.05)