Genome-wide joint analysis of single-nucleotide variant sets and gene expression for hypertension and related phenotypes

Table 1 Summary of top 5 genes associated with SBP, DBP, and HTN

	Chr	BP1	BP2	Gene	P_G+T	P_G	P_T	#SNV
SBP	1	27763371	27777626	TMEM222	1.94E-003	1.61E-004	5.87E-001	100
SBP	17	5486374	5490814	MIS12	1.63E-004	2.26E-003	4.46E-003	134
SBP	19	10528205	10581112	PDE4A	3.99E-004	1.30E-001	2.39E-004	311
SBP	3	57376936	57627630	DNAH12	7.87E-003	2.65E-004	9.92E-001	1691
SBP	19	32291486	32313186	MAG	1.74E-003	7.61E-001	3.22E-004	216
DBP	11	72239077	72244176	PHOX2A	1.45E-005	4.17E-001	5.22E-006	112
DBP	19	58182989	58213562	ZNF274	3.68E-004	4.03E-001	1.27E-004	234
DBP	3	10277571	10284767	GHRL	1.52E-004	4.94E-002	1.46E-004	118
DBP	11	43991253	44040694	ALX4	4.16E-004	1.16E-003	2.20E-002	458
DBP	1	61681046	61725423	TM2D1	5.52E-003	5.43E-004	7.86E-001	307
HTN	3	183042973	183066541	TRA2B	1.06E-005	4.91E-003	3.11E-005	496
HTN	7	27445802	27583281	HIBADH	4.05E-004	3.31E-005	7.38E-001	204
HTN	17	4004445	4143020	ZZEF1	3.86E-005	2.24E-002	1.27E-004	871
HTN	3	57277865	57480169	DNAH12	5.23E-003	1.13E-004	9.99E-001	327
HTN	5	131138142	131164051	SLC22A5	2.58E-003	1.34E-004	9.12E-001	151

BP1 first base pair of the gene, BP2 last base pair of the gene, Chr chromosome, P _G , P _G+T , P _T p values from 3 types of tests, and the bolded p value is the smallest of the 3 p values, #SNV number of single nucleotide variants in the gene region

ISSN: 1753-6561