Identification of interactions using model-based multifactor dimensionality reduction

BMC Proceedings

Table 1 Main effects and G × E interaction effects ^a

Trait	Env. Factor	SNP	Chr.	Position	Gene	p Value
HS	–	rs145441374	13	53 420 325	PCDH8	8.135 × 10⁻⁵
	–	rs1639	19	45 772 798	DMPK	1.883 × 10⁻⁵
	–	rs1991818	19	51 485 013	KLK7	4.645 × 10⁻⁵
DBP	–	rs2073371	21	32 493 204	TIAM1	7.396 × 10⁻⁵
SBP	Age	rs859400	1	175 375 334	TNR	0.0415

^a Results of model-based multifactor dimensionality reduction (MB-MDR) analyses for main effects of single-nucleotide polymorphisms (SNPs) and with sex and age (young, middle, old) as environmental factors (Env. Factor). Traits are hypertension status (HS), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Interactions with p value <0.05 are shown with chromosome (Chr.), position and associated gene

ISSN: 1753-6561