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Fig. 1 | BMC Proceedings

Fig. 1

From: A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures

Fig. 1

Empirical power of all 9 family-based rare-variant tests of association for 2 genes of interest, PDCD6IP and ZBTB38. When performing family-based rare-variant tests of association on gene PDCD61P, \( {w}_i \)-weighted tests (Q2, Q1, Q3, Q4) saw higher empirical power than \( {w_i}^{*} \)-weighted tests (Q2*, Q1*, Q4*, Q3*); for gene ZBTB38, this trend was reversed. The combined test (black) maintained consistent power between the 2 genes, and was less susceptible to the change in genetic architecture

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BMC Proceedings

ISSN: 1753-6561

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