Skip to main content

Table 2 Power for 10 genes selected to be representative of all 30 genes explored

From: A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures

Gene

\( {Q}_2 \)

\( {Q}_{2^{*}} \)

\( {Q}_1 \)

\( {Q}_{1^{*}} \)

\( {Q}_4 \)

\( {Q}_{4^{*}} \)

\( {Q}_3 \)

\( {Q}_{3^{*}} \)

Combined

High power

ARF4

0.425

0.315

0.07

0.075

0.885

0.585

0.785

0.435

0.58

DNASE1L3

0.525

0.315

0.13

0.055

0.53

0.365

0.455

0.365

0.325

MAP4

0.995

0.995

0.225

0.99

0.995

0.995

0.995

0.995

0.995

SCAP

0.995

0.82

0.54

0.17

0.99

0.98

0.985

0.78

0.945

Low power

CXCR6

0.025

0.015

0.005

0.01

0.025

0.03

0.025

0.035

0.025

PAK2

0.04

0.025

0.04

0.005

0.035

0.045

0.045

0.015

0.025

PTPLB

0.02

0.0

0.025

0.035

0.01

0.005

0.015

0.025

0.01

RAD18

0.025

0.005

0.05

0.04

0.005

0.005

0.02

0.015

0.01

Other representative genes

PDCD6IP

0.32

0.03

0.05

0.015

0.30

0.10

0.13

0.035

0.11

ZBTB38

0.09

0.325

0.10

0.21

0.08

0.295

0.07

0.325

0.19

 Mean Across All 30 Genes (SD)

0.18 (0.25)

0.18 (0.23)

0.08 (0.11)

0.11 (0.18)

0.22 (0.30)

0.20 (0.25)

0.17 (0.27)

0.17 (0.23)

0.17 (0.25)

  1. Statistical power is reported for all 9 tests across 10 different genes: the 4 genes with highest overall power, the 4 genes with lowest overall power, and 2 genes deemed representative of the remaining genes explored. The mean power for each test statistic across all 30 genes is reported at the bottom of the table