Table 3 Summary for all methods
From: Comparing family-based rare variant association tests for dichotomous phenotypes
Method | Design | Phenotype | Burden | C-alpha | SKAT-O | Covariate | Language | Computing time (hour) |
|---|---|---|---|---|---|---|---|---|
RV-TDT | Retrospective | Binary | Â | Â | Â | Â | C | 20 |
GEE-KM | Prospective | Binary/Continuous | √ | √ |  | √ | R | 40 |
PedCMC | Retrospective | Binary | √ |  |  |  | C | 1.7 |
PedGene | Retrospective | Binary | √ | √ |  |  | R | 40 |
FARVAT | Retrospective | Binary | √ | √ | √ |  | C | 1.7 |