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Table 3 Summary for all methods

From: Comparing family-based rare variant association tests for dichotomous phenotypes

Method Design Phenotype Burden C-alpha SKAT-O Covariate Language Computing time (hour)
RV-TDT Retrospective Binary      C 20
GEE-KM Prospective Binary/Continuous   R 40
PedCMC Retrospective Binary     C 1.7
PedGene Retrospective Binary    R 40
FARVAT Retrospective Binary   C 1.7