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Table 1 Type I error rates and 95 % confidence intervals for the CAPL-burden and CAPL-SKAT at α = 0.05

From: A combined association test for rare variants using family and case-control data

Population Number of variants CAPL-burden CAPL-SKAT
CEU 50 0.056 (0.049, 0.062) 0.047 (0.041, 0.052)
CEU 100 0.049 (0.043, 0.054) 0.042 (0.036, 0.047)
MXL 50 0.050 (0.043, 0.056) 0.045 (0.039, 0.050)
MXL 100 0.049 (0.043, 0.054) 0.054 (0.047, 0.060)
CEU + MXL 100 0.045 (0.039, 0.051) 0.043 (0.037, 0.048)