Powerful association test combining rare variant and gene expression using family data from Genetic Analysis Workshop 19

Table 1 Top 20 genes with adjusted p value of <0.05 from the Seq-aSum-VS test for either SNP or DBP

	Gene	Chr	# RVs	p Value_s	W _s	p ^*_s	p Value_D	W _D	p ^*_D
1	NAIF1	9	23	<0.002	1.306	<0.002	0.002	0.825	0.002
2	SPATA13-AS1	13	7	<0.002	0.986	<0.003	0.018	0.835	0.022
3	UTP11L	1	34	<0.002	0.828	<0.003	0.006	1.168	0.005
4	C1orf174	1	36	<0.002	2.473	<0.002	<0.002	2.049	<0.002
5	KRTAP23-1	21	2	<0.002	0.955	<0.003	<0.002	0.586	<0.004
6	ZNF14	19	49	<0.002	0.625	<0.004	0.012	0.788	0.015
7	LOC101926911	15	28	<0.002	0.526	<0.004	0.008	0.856	0.009
8	SGSH	17	45	0.002	1.839	0.001	0.004	0.842	0.005
9	UROD	1	6	0.002	1.523	0.001	0.040	1.870	0.021
10	HES2	1	13	0.002	0.858	0.002	0.016	0.694	0.023
11	CHRNB1	17	50	0.008	2.413	0.003	0.022	1.422	0.015
12	ZBTB47	3	42	0.004	1.106	0.004	0.076	1.465	0.052
13	MIR4467	7	2	0.004	0.879	0.005	0.006	0.848	0.007
14	GTF3A	13	31	0.006	0.918	0.007	0.002	1.178	0.002
15	HMGB4	1	20	0.012	1.593	0.008	0.062	1.248	0.050
16	TEKT2	1	27	0.012	1.481	0.008	0.006	1.782	0.003
17	COX8A	11	12	0.006	0.722	0.008	0.006	1.043	0.006
18	MED29	19	27	0.010	1.202	0.008	0.026	0.637	0.041
19	C11orf21	11	32	0.008	0.951	0.008	0.038	1.172	0.032
20	PRAMEF17	1	5	0.014	1.656	0.008	0.054	0.721	0.075

Chr chromosome, p ^*_s weight adjusted p value for SBP, p value _s p value for SBP, # RVs number of rare variants identified in the gene, W _s weight for SBP
Subscript D represents statistics for DBP

ISSN: 1753-6561