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Table 1 Results of the SNVs significantly associated with SBP under the copula model and results under the univariate model

From: Genetic association analysis based on a joint model of gene expression and blood pressure

SNV

MAF

Location

Copula

Univariate

\( \hat{\alpha_1} \) (SE)

p value

Adj. p value

\( \hat{\alpha_1} \) (SE)

p value

Adj. p value

rs10402825

0.04

CEACAM5 (protein coding)

30.77 (6.52)

2.40 × 10− 6

4.42 × 10− 2

32.21 (6.63)

6.18 × 10− 6

1.12 × 10− 1

rs7258524

0.04

CEACAM5 (upstream)

30.75 (6.56)

2.77 × 10− 6

4.42 × 10− 2

32.28 (6.67)

6.86 × 10− 6

1.71 × 10− 1

  1. Adj. p value is the adjusted p value with BH-correction; MAF denotes the minor allele frequency in this sample. The estimated Kendall’s τ between SBP adj and GE CEACAM5,adj is − 0.13. Note: The markers are in very high linkage disequilibrium (LD) (r = 0.99). SNVs rs34155934, rs35091611, and rs10415940 in the same gene are in perfect LD with rs7258524 and have identical association