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Table 2 Significant and consistent estimates of disease locus positions and their genetic effects using “Ever” and “Progression” phenotypes

From: Multipoint association mapping for longitudinal family data: an application to hypertension phenotypes

Gene*

Ever

Progression

Previous hits

\( \widehat{\tau} \) ± SE

Ĉ

p Value

\( \widehat{\tau} \) ± SE

Ĉ

p Value

FBLN2

13.6464 ± 0.00026

0.80

8.85 × 10−7

13.6462 ± 0.00030

0.88

2.47 × 10−6

L

C3orf19

14.6810 ± 0.00099

0.34

1.61 × 10−12

14.6802 ± 0.0010

0.34

6.87 × 10−11

L

C3orf20

14.7245 ± 0.00077

0.51

1.31 × 10−6

14.7244 ± 0.00091

0.45

2.81 × 10−7

L

OSBPL10

31.6853 ± 0.00051

0.41

7.69 × 10−8

31.6856 ± 0.00024

0.62

3.95 × 10−6

LG

CMTM8

32.3186 ± 0.00080

0.56

6.01 × 10−6

32.3183 ± 0.00052

0.70

1.20 × 10−5

 

BSN

49.6596 ± 0.00062

0.83

3.42 × 10−8

49.6594 ± 0.00077

0.77

3.58 × 10−6

 

RFT1

53.1117 ± 0.0012

0.37

4.07 × 10−6

53.1111 ± 0.0012

0.36

2.54 × 10−5

 

ADAMTS9

64.5214 ± 0.00028

0.53

1.05 × 10−11

64.5216 ± 0.00030

0.54

2.54 × 10−11

L

EPHA3

89.6014 ± 0.00042

0.80

1.41 × 10−6

89.6018 ± 0.00040

0.89

1.19 × 10−5

 

EPHA6

98.2999 ± 0.00047

0.41

3.57 × 10−8

98.2997 ± 0.00052

0.48

7.3 × 10−7

L

C3orf52

113.3097 ± 0.0026

0.62

6.55 × 10−9

113.3088 ± 0.0030

0.58

7.29 × 10−6

L

SIDT1

114.7743 ± 0.00039

0.78

8.45 × 10−7

114.7741 ± 0.00071

0.67

8.46 × 10−6

L

IFT122

130.7107 ± 0.0012

0.57

1.10 × 10−5

130.7118 ± 0.00060

0.71

4.90 × 10−7

 

RBP1

140.7325 ± 0.00019

0.65

6.40 × 10−7

140.7345 ± 0.00033

0.42

3.89 × 10−11

L

PLOD2

147.3469 ± 0.00098

0.34

3.56 × 10−6

147.3469 ± 0.0016

0.34

3.02 × 10−5

L

LEKR1

158.2181 ± 0.00036

0.72

1.66 × 10−10

158.2183 ± 0.00043

0.77

4.35 × 10−10

L

RSRC1

159.4005 ± 0.00059

0.51

4.35 × 10−6

159.4003 ± 0.00064

0.51

1.64 × 10−5

L

ECT2

174.0021 ± 0.00064

0.88

1.91 × 10−6

174.0022 ± 0.00063

1.00

2.92 × 10−7

L

PEX5L

181.0080 ± 0.0078

0.29

2.99 × 10−5

181.0145 ± 0.013

0.23

5.23 × 10−7

LG

LPP

189.5573 ± 0.00035

0.50

1.71 × 10−6

189.5574 ± 0.00022

0.53

7.05 × 10−6

 

OSTN

192.4272 ± 0.0018

0.73

5.33 × 10−14

192.4301 ± 0.0012

0.80

4.11 × 10−9

G

  1. Ĉ, the genetic effect estimate; G, previous GWAS hits; L, previous linkage hits; \( \widehat{\tau} \), the disease locus position estimate in cM
  2. *Because of space limitations, we list only the 2 phenotypes with consistent estimates for the disease locus positions (the difference between the 2 \( \widehat{\tau} \) for both phenotypes is less than 10−2 cM) and significant estimates for the genetic effects (both with P < 4.57 × 10−5, Bonferroni)