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Table 1 Heritability and GWA study results

From: Genome-wide association of trajectories of systolic blood pressure change

Marker CHR:POS Nearest Gene E/O Allele EAF Trajectory Class 2 (N up to 416) Trajectory Class 3 (N up to 224) Trajectory Class 4 (N up to 187) Trajectory Class 5 (N up to 136) Ordinal (N up to 633)
h2 = 0.12 [0.17] P = 0.2117 h2 = 0.57 [0.28] P = 0.0137 h2 = 0.94 [0.34] P = 0.0044 h2 = 0.87 [0.40] P = 0.0256 h2 = 0.23 [0.09] P = 0.0007
B SE P β SE P β SE P β SE P β SE P
rs17112252 5:151103540 ATOX1 A/C 0.96 0.47 0.08 1.0E-08 0.28 0.10 7.2E-03 −0.02 0.10 8.8E-01 0.08 0.10 4.2E-01 0.032 0.170 8.53E-01
rs17133935 7:44704204 OGDH G/A 0.18 0.06 0.04 1.5E-01 0.05 0.07 5.0E-01 0.12 0.07 1.0E-01 0.30 0.06 3.2E-07 0.308 0.081 1.62E-04
rs7857537 9:100337976 GABBR2 C/T 0.03 0.27 0.11 1.2E-02 0.46 0.21 2.8E-02 0.50 0.19 7.6E-03 0.89 0.17 5.1E-07 0.571 0.188 2.50E-03
rs4756864 11:16762663 PLEKHA7 a C/T 0.42 0.14 0.03 8.2E-06 0.15 0.05 3.0E-03 0.21 0.06 2.1E-04 0.26 0.05 1.7E-07 0.262 0.063 3.28E-05
rs2159537 17:12316500 MYOCD G/A 0.12 −0.03 0.06 6.0E-01 0.20 0.08 9.0E-03 0.10 0.08 2.6E-01 0.35 0.07 4.2E-06 0.472 0.097 1.44E-06
rs630539 17:37946870 NAGLU C/T 0.02 0.28 0.13 2.5E-02 0.51 0.25 4.4E-02 0.55 0.28 4.9E-02 0.89 0.17 1.0E-06 0.650 0.225 3.93E-03
rs11203213 21:43034914 PDE9A T/C 0.42 0.02 0.03 5.4E-01 0.16 0.05 1.0E-03 0.09 0.06 1.1E-01 0.17 0.05 4.6E-04 0.262 0.063 3.62E-05
rs762407 21:44005874 PDXK A/G 0.42 0.06 0.03 8.3E-02 0.17 0.05 9.1E-04 0.25 0.05 1.0E-06 0.11 0.05 3.3E-02 0.319 0.064 7.03E-07
  1. Results of the heritability estimates for the pairwise comparison of group membership with group 1 as the referent group and the ordinal analysis are presented for each test, as h2 [SE], p value. Results of the GWA study analyses including all SNPs that reached genome-wide significance (p < 1.3E-7) (highlighted in bold-italic) and those SNPs that reached suggestive significance (p < 1.6E-6) (highlighted in bold)
  2. CHR:POS chromosome and base pair position, E/O effect/other, EAF effect allele frequency estimated from total analytical sample, P p value, SE standard error of beta estimate
  3. aPreviously identified SBP-associated locus [11, 19]