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Table 1 Heritability and GWA study results

From: Genome-wide association of trajectories of systolic blood pressure change

Marker

CHR:POS

Nearest

Gene

E/O

Allele

EAF

Trajectory Class 2

(N up to 416)

Trajectory Class 3

(N up to 224)

Trajectory Class 4

(N up to 187)

Trajectory Class 5

(N up to 136)

Ordinal

(N up to 633)

h2 = 0.12 [0.17]

P = 0.2117

h2 = 0.57 [0.28]

P = 0.0137

h2 = 0.94 [0.34]

P = 0.0044

h2 = 0.87 [0.40]

P = 0.0256

h2 = 0.23 [0.09]

P = 0.0007

B

SE

P

β

SE

P

β

SE

P

β

SE

P

β

SE

P

rs17112252

5:151103540

ATOX1

A/C

0.96

0.47

0.08

1.0E-08

0.28

0.10

7.2E-03

−0.02

0.10

8.8E-01

0.08

0.10

4.2E-01

0.032

0.170

8.53E-01

rs17133935

7:44704204

OGDH

G/A

0.18

0.06

0.04

1.5E-01

0.05

0.07

5.0E-01

0.12

0.07

1.0E-01

0.30

0.06

3.2E-07

0.308

0.081

1.62E-04

rs7857537

9:100337976

GABBR2

C/T

0.03

0.27

0.11

1.2E-02

0.46

0.21

2.8E-02

0.50

0.19

7.6E-03

0.89

0.17

5.1E-07

0.571

0.188

2.50E-03

rs4756864

11:16762663

PLEKHA7 a

C/T

0.42

0.14

0.03

8.2E-06

0.15

0.05

3.0E-03

0.21

0.06

2.1E-04

0.26

0.05

1.7E-07

0.262

0.063

3.28E-05

rs2159537

17:12316500

MYOCD

G/A

0.12

−0.03

0.06

6.0E-01

0.20

0.08

9.0E-03

0.10

0.08

2.6E-01

0.35

0.07

4.2E-06

0.472

0.097

1.44E-06

rs630539

17:37946870

NAGLU

C/T

0.02

0.28

0.13

2.5E-02

0.51

0.25

4.4E-02

0.55

0.28

4.9E-02

0.89

0.17

1.0E-06

0.650

0.225

3.93E-03

rs11203213

21:43034914

PDE9A

T/C

0.42

0.02

0.03

5.4E-01

0.16

0.05

1.0E-03

0.09

0.06

1.1E-01

0.17

0.05

4.6E-04

0.262

0.063

3.62E-05

rs762407

21:44005874

PDXK

A/G

0.42

0.06

0.03

8.3E-02

0.17

0.05

9.1E-04

0.25

0.05

1.0E-06

0.11

0.05

3.3E-02

0.319

0.064

7.03E-07

  1. Results of the heritability estimates for the pairwise comparison of group membership with group 1 as the referent group and the ordinal analysis are presented for each test, as h2 [SE], p value. Results of the GWA study analyses including all SNPs that reached genome-wide significance (p < 1.3E-7) (highlighted in bold-italic) and those SNPs that reached suggestive significance (p < 1.6E-6) (highlighted in bold)
  2. CHR:POS chromosome and base pair position, E/O effect/other, EAF effect allele frequency estimated from total analytical sample, P p value, SE standard error of beta estimate
  3. aPreviously identified SBP-associated locus [11, 19]