Table 2 List of genes with top pathway-based signals for real and simulated phenotypes
Phenotype | Gene (variant) | p Value | |
|---|---|---|---|
Unadjusted | Bonferroni adjusted | ||
Real phenotypes | |||
DBP | PRKCA (rs1010546) | 0.0014 | 0.0291 |
SBP | PRKCA (rs1010546) | 0.0015 | 0.0316 |
MAP | PRKCA (rs1010546 | 0.0006 | 0.0117 |
PP | INSR (rs3815902) | 0.0130 | 0.2730 |
Hypertension | PRKCA (rs1010546) | 0.0029 | 0.0624 |
Simulated phenotypes | |||
DBP | PRKCA (rs2227857) | 0.0025 | 0.0528 |
SBP | PRKCA (rs2227857) | 0.0009 | 0.0205 |
MAP | PRKCA (rs2227857) | 0.0004 | 0.0080 |
PP | INSR (rs2860177) | 0.0359 | 0.7549 |
Hypertension | ATP1A4 (rs11265338) | 0.0045 | 0.0953 |