Skip to main content
Fig. 2 | BMC Proceedings

Fig. 2

From: A multistep approach to single nucleotide polymorphism–set analysis: an evaluation of power and type I error of gene-based tests of association after pathway-based association tests

Fig. 2

Comparison of power for multistep and conventional approaches. a. Comparison of power at each gene for multistep VC test -VC test versus the single-step VC test approach, with significance evaluated at alpha levels of 0.05 and 0.005, respectively. The red points are genes for which the single-step approach has higher power (below the line y = x) and the blue points are instances where our multistep approach has higher power (above the line y = x). There are quite a few instances when the multistep approach offers relatively large improvements in power compared to the single-step gene-based test. b. Comparison of power for Burden test - VC test versus VC test . c. Comparison of power for VC test -Burden test vs. Burden test . d. Comparison of power for Burden test -Burden test versus Burden test . Notice again that there are many instances where the multistep approach offers improvements in power over the single-step gene-based test. Overall we see that our method outperforms the single-step tests by a larger amount, on average, when the first and second step are consistent (VC test -VC test and Burden test- Burden test )

Back to article page