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Table 1 Power to detect true-positive gene–medication interactions at CYP3A43 using 2 approaches. Gene–medication interactions (200 replicates) were simulated to be 6.2 mm Hg at 3 single nucleotide polymorphisms (SNPs) representing a range of minor allele frequencies (MAFs) (0.1 to 5.4 %)

From: Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family-based data

 

Interaction model

Med-diff approach

βInt

SEInt

1DF PInt

2DF PSNP, Int

βDiff

SEDiff

1DF PDiff

2DF PJoint

chr7:99457518-A (0.1 % MAF)

 Mean

12.35

15.42

4.3E-01

3.4E-01

11.82

15.29

4.2E-01

3.3E-01

 Min

−21.90

14.55

1.3E-03

2.9E-04

−23.68

14.18

1.3E-03

6.1E-05

 Max

51.85

16.69

1

9.9E-01

50.11

16.64

1

9.9E-01

 Median

12.45

15.40

3.9E-01

2.4E-01

10.57

15.26

3.8E-01

2.3E-01

 Replicates P <0.05 of 141 converged

12.1 %

17.0 %

 

13.5 %

18.4 %

chr7:99454482-G (0.8 % MAF)

 Mean

5.20

8.61

4.5E-01

5.0E-01

4.10

8.25

4.3E-01

4.9E-01

 Min

−23.10

6.00

1.0E-03

2.3E-03

−24.83

5.96

1.4E-03

3.9E-03

 Max

29.80

12.37

1

1

30.15

12.51

9.9E-01

9.9E-01

 Median

5.45

8.37

4.5E-01

5.1E-01

4.76

7.88

4.2E-01

5.2E-01

 Replicates P <0.05 of 190 converged

7.9 %

6.3 %

 

9.5 %

5.8 %

chr7:99457605-C (5.4 % MAF)

 Mean

5.11

2.60

1.3E-01

7.5E-02

4.85

2.63

1.5E-01

7.3E-02

 Min

−3.20

2.30

1.9E-06

8.2E-06

−2.67

2.36

1.6E-06

2.8E-07

 Max

13.44

2.92

9.8E-01

7.0E-01

13.59

3.02

9.9E-01

8.9E-01

 Median

4.97

2.60

5.6E-02

2.2E-02

4.82

2.62

6.4E-02

2.0E-02

 Replicates P <0.05 of 200 converged

47.5 %

66.0 %

 

43.5 %

66.5 %

  1. β Effect estimate, DF degrees of freedom, Diff Difference, Int interaction, Joint Joint estimates of both interaction and main genetic effects, MAF minor allele frequency, P p value, SE standard error