Using next-generation DNA sequence data for genetic association tests based on allele counts with and without consideration of zero inflation

Table 1 Overall type I error rates

Response variable	Explanatory variable	Regression model	# p values	# Nonmissing p values	% Nonmissing p values	% Nonmissing p values under 0.05
AAC	Adjusted DBP	Negative binomial (NB)	8957	8871	99.0	0.388
		Zero-inflated NB	8957	6608	73.8	0.064
		Hurdle NB	8957	6585	73.5	0.035
AAC/total read depth	Adjusted DBP	Standard linear	8957	8947	99.9	0.062
AAC/total read depth	Adjusted DBP	Robust linear	8957	1509	16.8	0.068
Adjusted DBP	AAC/total read depth	Standard linear	8957	8947	99.9	0.062
Adjusted DBP	AAC/total read depth	Robust linear	8957	8917	99.6	0.127

ISSN: 1753-6561