Table 1 (abstract P-078). Summary of CSPR, Qp (relative to clone #1) and maximum growth in all the systems. Clone #1 was by far the best candidate for perfusion by reaching a productivity of about 1 g/L/day at SP4. The three other clones, despite their different growth and specific productivities all performed a productivity close to 0.5 g/L/day on SP4
| Â | Semi-conti | Perfusion | Semi-conti | Perfusion | Ranking | Fed-batch | Semi-conti | Perfusion |
|---|---|---|---|---|---|---|---|---|
Clone | CSPRmin | CSPRSP4 | Qp | Qp-SP4 | - | VCDmax | VCDmax | VCDSP4 |
- | pL/cell/day | pL/cell/day | - | - | - | 106·VC/mL | 106·VC/mL | 106·VC/mL |
#1 | 23.5 | 21.7 (±0.8) | 1 | 1 | 2 | 25.3 | 44.5 | 55.4 (±0.1) |
#2 | 27.5 | 28.3 (±0.3) | 0.82 | 0.67 | 4 | 15.4 | 36.4 | 42.7 (±1.1) |
#3 | 15.2 | 17.3 (±0.3) | 0.28 | 0.31 | 1 | 31.6 | 70.0 | 72.7 (±0.7) |
#4 | 27.1 | 24.8 (±1.3) | 0.67 | 0.59 | 3 | 15.5 | 36.9 | 44.7 (±5.5) |